044 IL-2C treatment expands regulatory T cells in vivo and arrests development of murine alopecia areata

Alopecia Areata (AA) is a common autoimmune disease characterized by the loss of immune privilege hair follicle. CD8+ T cells have been identified as main effectors in AA, however, little known about role regulatory (Tregs) and why they fail to control disease. The imbalance Tregs: thought influence development many diseases. Enrichment compartment has gaining momentum field currently there are ongoing clinical trials involving Treg therapy treatment for We were interested exploring effect enhancing numbers on onset AA murine C3H skin graft-induction model. In vivo with recombinant IL-2 complexed anti-IL-2 monoclonal antibody (IL-2C) resulted selective expansion CD4+ CD25+ FoxP3+ Tregs enhanced expression functional markers compared IgG control. Both continuous transient IL-2C complete prevention AA. Continuous an increased frequency (2,652 vs. 594 Tregs/g skin), suggesting their protective follicle tolerance. levels remained elevated at 3 months after stopping treatment, indicating how may deliver long-lasting tolerogenic benefits. Ongoing studies elucidate potential inhibit during active Findings from these provide translational insight into use enrichment therapeutic option patients.